Dioxin and Estrogen Signaling in Lung Adenocarcinoma Cells with Different Aryl Hydrocarbon Receptor/Estrogen Receptor α Phenotypes
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چکیده
منابع مشابه
Estrogen receptor and aryl hydrocarbon receptor signaling pathways
Estrogen receptors (ERs) and the aryl hydrocarbon receptor (AhR) are ligand activated transcription factors and members of the nuclear receptor and bHLH-PAS superfamilies, respectively. AhR is involved in xenobiotic metabolism and in mediating the toxic effects of dioxin-like compounds. Crosstalk has been observed among AhR and nuclear receptors, but has been most well studied with respect to E...
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Even before the first vertebrates appeared on our planet, the aryl hydrocarbon receptor (AHR) gene was present to carry out one or more critical life functions. The vertebrate AHR then evolved to take on functions of detecting and responding to certain classes of environmental toxicants. These environmental pollutants include polycyclic aromatic hydrocarbons (e.g., benzo[a]pyrene), polyhalogena...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2013
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2012-0497oc